Streamlining Bioprocessing

Assessment of expression levels and affinity without purification
I'm Interested
biopocessing protein production

What does FIDA bring
to Bioprocessing?


Early-stage analysis

  • Applied in both upstream and downstream bioprocessing
  • At-line and offline mode
  • Process acceleration thanks to early QC

Efficient protein production

  • Functional validation in unpurified samples
  • Membrane protein detergent screening
  • Quantification of both high and low concentrations
  • Down to 2–6% precision in downstream process

Precise characterization

  • Kd – binding strength measurement
  • Sample stability through size measurement
  • Oligomerisation and  polydispersity index
  • Validated for previously unseen precision in viscosity/size assessment in commercial processes

In-depth quality control

  • Aggregation measurement: quantified stability and quality of the product
  • Behaviour of multi-protein systems in bioprocessing thorough protein-protein interaction analysis
  • Viscosity measured and compensated


  • Automated
  • Calibration free
  • At-line alternative to sending samples to central analytics
  • Simple UX for non-lab personnel to operate

Time efficient

  • Down to 4 min of analysis time
  • Short protocols
  • Short and generic assay development


Simultaneous expression level and affinity measurements
No sample preparation
Can be operated by process personnel
Early detections


Work in crude matrixes
Triple temperature control
Automated workflow
Built-in QC (aggregation, viscosity, polydispersity)


Accurate determination of dilute phase concentration
Relative droplet size distributions
Kinetics of droplet formation and maturation into amyloid fibrils
Determination of binding affinity between the polypeptide undergoing LLPS and LLPS-modulating compounds

Targeting common Bioprocessing Challenges

Monitoring protein aggregation
FIDA quantifies aggregates present in the sample and delivers a relative overview of the sizes of aggregates. FIDA QC scans can be done at any stage of the process, pre or post purification, formulation or after a prolonged storage. Aggregation monitoring allows our users to make informed adjustments in their production parameters and storage conditions.
Purification conditions
Size and quality tracking during different stages of the purification process make it possible to identify optimal conditions for achieving high yield and quality.
Protein (product) stability
Measurement of size changes overtime and under diverse conditions makes it possible to identify environmental settings that slow down protein degradation, and guide the development of protein formulations of improved stability.
Cell culture productivity assessment
FIDA can provide information about protein behaviour in solution. This information can be incorporated as a quality control step combined with other strategies and technologies.
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