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Publications
In-solution Characterization of Biomolecular Interaction Kinetics under Native Conditions
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Posters
Changing the game of amyloid fibril and protein condensate research with FIDA
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Publications
Continuous Titration Based Method for Rapid In-Solution Analysis of Non-Covalent Interactions
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Publications
Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug
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Posters
Developing new tools for rapid quantification of viral vectors – a proof of concept
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Publications
Autoantigen TRIM21 (Ro52) assembles pro-1 inflammatory immune complexes following lytic cell death
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Videos
How to enable in solution quantification of small molecule protein interactions? - Using FIDA Lambda Dynamics in drug discovery
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Publications
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures
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Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
