Featured in this Biophysical Reviews paper, Flow Induced Dispersion Analysis (FIDA) is named among the modern biophysical platforms driving what the authors call state-centric biophysics: the shift from measuring one isolated property to reading the molecular states, binding affinity, kinetics, stability, hydrodynamic size, ligand occupancy and assembly state, that actually govern a molecule's mechanism, selectivity and therapeutic effect. FIDA earns its place because it quantifies noncovalent interactions and hydrodynamic radius (size) directly in solution, under native conditions and from only nanolitre sample volumes, delivering several of those state descriptors from a single, immobilisation-free measurement. The review builds its case with drug-discovery examples in targeted protein degradation, molecular glues, the HSP90 chaperone cycle and state-selective KRAS G12C inhibition, exactly the settings where the in-solution binding and size data FIDA provides complement structural and surface-based methods.