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Characterising Lipid Nanoparticles with FIDA: Sizing, PDI, Aggregation, Interactions, Viscosity and Binding Capacity
Emil G. P. V. Stender, Ph.D.1, Kritika S. Ray, Dr. rer. nat.1, Adam Coln Hundahl, Ph.D.1 and Henrik Jensen, Ph.D.
This Fidabio poster demonstrates how lipid nanoparticles (LNPs) can be comprehensively characterised on a single platform, from size and quality to biomolecular interactions. Flow Induced Dispersion Analysis (FIDA), on a Fida Neo instrument, was used to measure LNP hydrodynamic radius, polydispersity index (PDI) and aggregation state in both simple buffers and serum/plasma, and to determine the binding affinity and surface binding capacity of an anti-PEG antibody to LNPs while tracking sample viscosity. It is an example of using FIDA to characterise nanoparticle formulations and their biomolecular interactions directly in complex biological matrices.
