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Exploring endothelial protein c receptor as a therapeutic target: mapping distribution and correlation with nanoparticle targeting
Grace D.M. Eriksen, Martin Bak, David Schultz, Heidi Arps, Doha Ghannam, Anja Brus, Tsinat Berhane, Andrew J.Urquhart
This poster from the Technical University of Denmark demonstrates how Flow Induced Dispersion Analysis (FIDA) was used to measure antibody binding to the endothelial protein C receptor (EPCR), a candidate therapeutic target for directing nanoparticle delivery. FIDA determined the antibody's binding affinity to a recombinant, epitope-mapped EPCR (dissociation constant ~750 nM), complementing tissue-distribution and nanoparticle-targeting data. It is an example of using FIDA to measure antibody–antigen binding affinity in solution.
