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Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection
Nature Cell Biology 2026
Hodgson, R.E., Huang, WP., Lang, R. et al.
This study found that the ALS/FTD-linked protein TDP-43 acts as a negative regulator of paraspeckle condensation, requiring both its ability to self-polymerize and to bind RNA, and links restoring this balance to neuroprotection. Flow Induced Dispersion Analysis (FIDA) was used, through a Taylor dispersion-induced phase separation (TDIPS) assay, to measure condensate formation and stability, showing that FUS readily forms condensates while co-injection of TDP-43 drives a burst of monomerization. It is an example of using FIDA to monitor liquid–liquid phase separation and quantify condensate formation and stability in solution.
