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Publications
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry
Author Information
Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R., & Kjems, J.
PNAS 2021
Publications
2021
Publications
Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation
Author Information
Stender, E. G. P., Ray, S., Norrild, R. K., Larsen, J. A., Petersen, D., Farzadfard, A., Galvagnion, C., Jensen, H., & Buell, A. K.
Nature Communications 2021
Publications
2021
Publications
Bi-directional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners
Author Information
Christensen, N. R., Pedersen, C. P., Sereikaite, V., Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T., Otzen, D., Teilum, K., Madsen, K. L., & Strømgaard, K.
iScience 2022
Publications
2022
Publications
The Protein-Templated Synthesis of Enzyme-Generated Aptamers
Author Information
J.Vacacela, A.Schaap-Johansen, P. Manikova, P.Marcatili, M.Prado, Y.Sun, J.Ashley
Angewandte Chemie Int. Ed. 2022
Publications
2022
Publications
Quantification of Structural Integrity and Stability Using Nanograms of Protein by Flow-Induced Dispersion Analysis
Author Information
Morten E. Pedersen, Jesper Østergaard & Henrik Jensen
Molecules 2022
Publications
Publications
Assessment of immunogenicity and drug activity in patient sera by flow-induced dispersion analysis
Author Information
Morten E. Pedersen, Jesper Østergaard, Bente Glintborg, Merete L. Hetland & Henrik Jensen
Scientific Reports 2022
Publications
2022
Publications
A lipid transfer protein ensures nematode cuticular impermeability.
Author Information
Njume, F. N., Razzauti, A., Soler, M., Perschin, V., Fazeli, G., Bourez, A., Delporte, C., Ghogomu, S. M., Poelvoorde, P., Pichard, S., Birck, C., Poterszman, A., Souopgui, J., Van Antwerpen, P., Stigloher, C., Vanhamme, L., & Laurent, P.
iScience 2022
Publications
2022
Publications
Antigen footprint governs activation of the B cell receptor
Author Information
Ferapontov, A., Omer, M., Baudrexel, I. et al.
Nature Communications 2023
Publications
2023
Publications
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes
Author Information
Wade, J., Rimbault, C., Ali, H., Ledsgaard, L., Rivera-de-Torre, E., Abou Hachem, M., Boddum, K., Mirza, N., Bohn, M. F., Sakya, S. A., Ruso-Julve, F., Andersen, J. T., & Laustsen, A. H.
Bioconjugate Chemistry 2022
Publications
2022
Publications
FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC
Author Information
Helena Ø. Rasmussen, Amit Kumar, Ben Shin, Fisentzos Stylianou, Lee Sewell, Yingqi Xu, Daniel E. Otzen, Jan Skov Pedersen, Steve J. Matthews
Journal of Molecular Biology 2023
Publications
2023
Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
