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Technical Notes & White Papers
In-solution Kinetics Ebook - A guide to unconstrained Molecular Analysis
Author Information
Hasse Hedeby, Maja Wasilczyk, Brian Sorensen, Henrik Jensen
Technical Notes & White Papers
2025
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Publications
In-solution Characterization of Biomolecular Interaction Kinetics under Native Conditions
Author Information
Philipp Willmer, Emil G. P. Stender, Kritika Sahni Ray, Adam C. Hundahl, Rodolphe Marie, Henrik Jensen
Analytical Chemistry 2025
Publications
2025
Posters
Changing the game of amyloid fibril and protein condensate research with FIDA
Author Information
Einar Halldórsson; Emil G. P. V. Stender, Ph.D.
Posters
2025
Publications
Improvement in protein HSQC spectra from addition of betaine
Author Information
Finn O’Dea, Aiden J. Seargeant, Jessica Hurcum, Rodolpho do Aido-Machado, Michelle L. Rowe, Nicola J. Baxter, Jon P. Waltho, Jon R. Sayers & Mike P. Williamson
Journal of Biomolecular NMR 2025
Publications
2025
Publications
Continuous Titration Based Method for Rapid In-Solution Analysis of Non-Covalent Interactions
Author Information
Philipp Willmer, Adam C. Hundahl, Rodolphe Marie, Henrik Jensen
Chemistry–Methods 2025
Publications
2025
Publications
Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug
Author Information
Alexander I. P. Taylor; Yong XuMartin Wilkinson; Pijush Chakraborty; Alice Brinkworth; Leon F. Willis; Anastasia Zhuravleva; Neil A. Ranson; Richard Foster; Sheena E. Radford
Journal of the American Chemical Society 2025
Publications
2025
Selective Targeting of Pathogenic Tau Seeds via a Novel VHH
Author Information
Ankit Gupta, Richard Liu, Devin Keely, Victoria Sunderman, Yogesh Tak, Katerina Kostantoulea, Sandi Jo Terpack1 Charles L. White III, William P. Russ, Josep Rizo, Nikolaos Louros, Jaime Vaquer-Alicea, Marc I. Diamond
2025
Posters
Developing new tools for rapid quantification of viral vectors – a proof of concept
Author Information
P. Santos, C. Stephens, A. Peon, J.D. Czulak, A. Guerreiro, F. Canfarotta, O. Burns
Posters
2024
Publications
The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death
Author Information
Jones, Dustin, et.al.
Science Immunology 2026
Publications
2026
Videos
How to enable in solution quantification of small molecule protein interactions? - Using FIDA Lambda Dynamics in drug discovery
Author Information
Henrik Jensen, Ph.D.
Videos
2024
Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
