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Publications
Lignin Molar Mass Estimation by Dispersion Analysis
Author Information
Tor I. Simonsen, Demi T. Djajadi, Andrea Ponzecchi, Claudia Crestini, Matteo Gigli, Massimo Sgarzi, Sune T. Thomsen
Macromolecular Rapid Communications 2025
Publications
2025
Rabies Virus Phosphoprotein Exhibits Thermoresponsive Phase Separation with a Lower Critical Solution Temperature
Author Information
Fella Bouchama, Khadeeja Mubashira, Caroline Mas, Aline Le Roy, Christine Ebel, Jean-Marie Bourhis, Thomas Zemb, Sylvain Prevost, Marc Jamin,
2025
Publications
Divergent effects of pathological α-synuclein truncations and mutations on phase separation
Author Information
Soumik Ray, Cecilia Chiodaroli, Azad Farzadfard, Antonin Kunka, Katharina Helga Schott, Sophie Hertel, Kristina Mojtic, Louise Kjær Klausen, Céline Galvagnion, Alexander K. Buell
bioRxiv (preprint) 2024
Publications
2024
Publications
Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability
Author Information
Harper, K.L., Harrington, E.M., Hayward, C. et al.
Nature Communications 2024
Publications
2024
Publications
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Author Information
Evelyn R. Smith, Emma D. Turner, Mahmoud A. S. Abdelhamid, Timothy D. Craggs, Alison E. Twelvetrees
iScience 2026
Publications
2026
Proteome-scale quantification of the interactions driving condensate formation of intrinsically IDPs
Author Information
Rasmus K. Norrild, Sören von Bülow, Einar Halldórsson, Kresten Lindorff-Larsen, Joseph M. Rogers, Alexander K. Buell
2024
DciA, the Bacterial Replicative Helicase Loader, Promotes LLPS in the Presence of ssDNA
Author Information
Stéphanie Marsin, Sylvain Jeannin, Sonia Baconnais, Hélène Walbott, Gérard Pehau-Arnaudet, Magali Noiray, Magali Aumont-Nicaise, Emil G.P. Stender, Claire Cargemel, Romain Le Bars, Eric Le Cam, Sophie Quevillon-Cheruel
2025
Native Taylor/Non-Taylor Dispersion–Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening
Author Information
Jonathan Eisert, Edvaldo Vasconcelos Soares Maciel, Verena Dederer, Aylin Berwanger, Henry J. Bailey, Ivan Đikić, Stefan Knapp, Martin Empting, Sebastian Mathea, Henrik Jensen, Frederik Lermyte
2025
Publications
Nanobodies raised against the cytotoxic α-synuclein oligomer are oligomer-specific and promote its cellular uptake
Author Information
Janni Nielsen, Jannik N. Pedersen, Giulia Kleijwegt, Jan S. Nowak, D. Otzen et all.
npj Biosensing 2025
Publications
2025
Publications
Screening de. novo designed protein binders in unpurified lysate using flow induced dispersion analysis
Author Information
Francisca Pinheiro; Jan S. Nowak; Elena Zueva; Emily C. Pheasant; Ida Kjærsgaard Grene; Vili Lampinen; Magnus Kjaergaard.
Protein Science 2025
Publications
2025
Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
