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Publications
Taylor-dispersion induced phase separation for efficient characterisation of protein condensate formation
Author Information
Rasmus Krogh Norrild, Thomas Oliver Mason, Lars Boyens-Thiele, Soumik Ray, Joachim Berg Mortensen, Anatol W. Fritsch, Juan M. Iglesias-Artola, Louise Kjær Klausen, Emil Georg Palmkvist Stender, Henrik Jensen, Alexander Kai Buell
Angewandte Chemie Int. Ed. 2024
Publications
2024
Posters
Applying FIDA for in-solution binding kinetics
Author Information
Kritika S. Rey, Adam C. Hundahl, Emil G. P. Stender, Agnieszka Lisicka, Peter Spies and Henrik Jensen
Posters
2024
Publications
Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow’s milk allergy
Author Information
Katrine Lindholm Bøgh, Ditte Møller Nielsen, Hossein Mohammad-Beigi, Heidi Frahm Christoffersen, Lotte Neergaard Jacobsen, Rasmus Krogh Norrild, Birte Svensson, Klara Schmidthaler, Zsolt Szépfalusi, Julia Upton, Thomas Eiwegger, Hans Bertelsen, Alexander Kai Buell, Laila Vestergaard Sørensen, Jeppe Madura Larsen
Food Research International 2024
Publications
2024
Posters
Small Molecule interactions with Membrane Proteins
Author Information
Emil G.P.V. Stender, PhD., Hasse Hedeby, Juanitta Julsgart
Posters
2024
Publications
Thermodynamic characterization of amyloid polymorphism by microfluidic transient incomplete separation
Author Information
Azad Farzadfard, Antonin Kunka, Thomas O. Mason, Jacob A. Larsen, Rasmus K. Norrild, Elisa T. Dominguez, Soumik Ray and Alexander Buell
Chemical Science 2024
Publications
2024
Publications
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Author Information
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E. Otzen, Jan Johansson, Axel Abelein
Protein Science 2023
Publications
2023
Posters
Applications of FIDA in Protein Science
Author Information
Toby Allen, Liz Flavell, Heather Hayes, Stephen Moss, Josh Shaw, Jack Wright, Steven Harborne, Duncan Smith
Posters
2023
Publications
Immobilization-Free Binding and Affinity Characterization of Higher Order Bispecific Antibody Complexes Using Size-Based Microfluidics
Author Information
Andreas V. Madsen, Oscar Mejias-Gomez, Lasse E. Pedersen, Kerstin Skovgaard, Peter Kristensen, and Steffen Goletz
Analytical Chemistry 2022
Publications
2022
Application Notes
In-solution characterization of affinity and structural properties of the FcRn IgG1 Fc interaction during product development
Author Information
In-solution characterization of affinity and structural properties of the FcRn IgG1 Fc interaction during product development
Matt Gothard, David Pérez-Martínez, and Emil G. P. V. Stender
Application Notes
2023
Posters
Characterising Multivalent Complex Formation Using Controlled Complex Lifetime in Fida 1
Author Information
Emil Georg Palmkvist Vangsgaard Stender, PhD, Kritika Sahni Ray, Dr. rer. nat.
Posters
2023
Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
